Cancer 1980 Jul 15;46(2):372-9

Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adult
with distinctive clinico-pathologic features

Craig JR, Peters RL, Edmondson HA, Omata M

Abstract

Clinical and pathologic features of 23 patients with a distinctive histologic
and clinical variant of hepatocellular carcinoma are summarized. The variant
pattern of hepatocellular carcinoma is most common in the age group 5--35 years
and occurs equally in either sex. The distinctive histologic features include 1)
deeply eosinophilic neoplastic hepatocytes, many of which contain
intracytoplasmic hyaline globules and distinct pale bodies and 2) fibrosis
arranged in a lamellar fashion around the neoplastic hepatocytes. The histologic
and gross features of the tumor have been confused both with focal nodular
hyperplasia and with hepatocellular adenoma. The average survival of 32 months
and the high operability rate of 48% far exceed the survival or operability for
ordinary hepatocellular carcinoma. Thus, this tumor type must be recognized and
considered separately when evaluating therapeutic results in large series of
patients with hepatocellular carcinoma